"This year's prize recipients are scientific pioneers who have delivered novel concepts and opened the door to uncharted fields at the forefront of immunological research," said Dhavalkumar D. Patel, M.D., Ph.D, Head of Research Europe and Global Head, Autoimmunity, Transplantation and Inflammation research at the Novartis Institutes for BioMedical Research. "We are proud to sponsor these prizes as part of our continued commitment to supporting innovative research in immunology."
The winners were selected by an independent jury of seven world-class immunologists for their groundbreaking research into the biology of the immune system. Each recipient has had a tremendous impact on the understanding of T-cell mediated mechanisms such as tolerance (basic immunology) and how these principles can be exploited to design therapeutic approaches (clinical immunology).
The Novartis Prize for Basic Immunology 2016 is shared by John Kappler (National Jewish Health, USA), Philippa Marrack (National Jewish Health, USA) and Harald von Boehmer (Emeritus, Harvard Medical School, USA) for their work in demonstrating how the immune system is able to discriminate "self" from "non-self" through a process in the thymus based on positive and negative selection via T-cell receptor mediated recognition of peptide-MHC complexes.
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