Experimental Drug shows - Resistant leukemias

Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia. Results of the research by Johns Hopkins Kimmel Cancer Center investigators, described March 6 in the journal Blood, show that two doses a day of TTT-3002 eliminated leukemia cells in a group of mice within 10 days. The treatment performed as well as or better than similar drugs in head-to-head comparisons.

More than 35 percent of acute myeloid leukemia (AML) patients harbor a mutation in the gene FMS-like tyrosine kinase-3 (FLT3). Normal FLT3 genes produce an enzyme that signals bone marrow stem cells to divide and replenish. But when FLT3 is mutated in some AML patients, the enzyme stays on permanently, causing rapid growth of leukemia cells and making the condition likely to relapse after treatment.

Many investigators are developing and testing drugs designed to block the FLT3 enzyme's proliferation, several of which are now in clinical trials. So far, their effectiveness has been limited, according to Donald Small, M.D., Ph.D., the Kyle Haydock Professor of Oncology and director of pediatric oncology at Johns Hopkins. Small led a team of researchers who originally cloned the FLT3 gene and linked it to leukemia a decade ago.

Benzene - Health affects

Benzene is found in the air, water, and soil. You can be exposed to small amounts of benzene outdoors, where the air can contain low levels from tobacco smoke, automotive service stations, vehicle exhaust, and industrial emissions. You can be exposed to higher levels of benzene near gas stations, hazardous waste sites, or industrial facilities.

You can be exposed to benzene indoors at home, where the air can contain higher levels of benzene than outdoor air, from products such as glue, paint, furniture wax, and detergent.

Benzene is listed as a human carcinogen in the Twelfth Report on Carcinogens published by the National Toxicology Program because it has been known to cause cancer. Long-term exposure to high levels of benzene can cause leukemia.

Breathing very high levels of benzene, or eating or drinking foods contaminated with high levels of benzene, can cause death. Eating or drinking foods contaminated with high levels of benzene can also cause vomiting and stomach irritation. Small amounts of benzene, which are not harmful, can be found in fruit, fish, vegetables, nuts, dairy products, beverages, and eggs.

Short-term exposure to high levels of benzene by breathing or eating affects the central nervous system and can cause paralysis, coma, convulsions, dizziness, sleepiness, rapid heart rate, tightness of the chest, tremors, and rapid breathing.

If you work at a facility that uses benzene, breathing high levels of benzene can cause irreversible brain damage, unconsciousness, cardiac arrest, blurred vision, headaches, tremors, confusion, and fatigue. In women, it can shrink ovaries and cause menstrual irregularity. Spilling benzene on your skin can cause redness, sores, scaling, and drying of the skin. If benzene contacts the eyes, it can cause irritation and damage to the cornea.

Long-term exposure to benzene can decrease red blood cells, leading to anemia. It can also cause excessive bleeding and affect the immune system, increasing the chance of infection.