Scientists have for the first time replicated the full
course of events underlying the development of Alzheimer's disease
inside a lab. A novel 3D culture system replicates the course of
Alzheimer's, which doctors feel could significantly reduce time and cost
of drug development.
Researchers from the Massachusetts General Hospital in Boston showed that the deposition of beta-amyloid plaques in the brain is the first step in a cascade leading to the devastating neurodegenerative disease. They also identified the essential role in that process of an enzyme, inhibition of which could be a therapeutic target.
The MGH team used a gel-based, 3D culture system to grow human neural stem cells that carried variants in two genes — the amyloid precursor protein and presenilin 1 — known to underlie early-onset Familial Alzheimer's Disease (FAD). Both the genes were co-discovered in lead researcher Rudolph E Tanzi's laboratory.
Researchers from the Massachusetts General Hospital in Boston showed that the deposition of beta-amyloid plaques in the brain is the first step in a cascade leading to the devastating neurodegenerative disease. They also identified the essential role in that process of an enzyme, inhibition of which could be a therapeutic target.
The MGH team used a gel-based, 3D culture system to grow human neural stem cells that carried variants in two genes — the amyloid precursor protein and presenilin 1 — known to underlie early-onset Familial Alzheimer's Disease (FAD). Both the genes were co-discovered in lead researcher Rudolph E Tanzi's laboratory.
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