Lipidic Nanoparticles (LNPs) Since decades, LNPs and lipidic
nanopellets have been successfully employed for oral drug delivery as
first and second generation nano-structured lipidic systems containing
lipid matrices, respectively.
Solid lipid nanoparticles (SLNs) are the third generation nanostructured colloidal carriers ranging in size between 1 and 1000 nm, frequently used as an alternative over traditional polymeric nanoparticles. Their colloidal dimension provides high drug pay load, controlled drug release, drug targeting, drug protection and stability. Upon peroral delivery, SLNs are readily taken up by intestinal lymphatics owing to their lipidic nature and nanosized structure to enhance the oral bioavailability. The increasing attention in SLNs is due to their combined biodegradable and bio-acceptable nature coupled with efficient drug delivery characteristics and hassle-free method of preparation vis-a-vis polymeric nanoparticles.
Nanostructured lipidic carriers (NLCs), another third generation of nanoparticles, size ranging between 10 and 1000 nm, consist of mixture of solid and liquid lipids. Incorporation of liquid lipid can improve the loading capacity of drugs in the NLCs. Such NLCs tend to overcome the limitations of SLNs such as risk of gelation, uncontrolled release, decreased chemical stability and drug leakage during storage due to polymorphism of lipids. Commonly employed methods to produce NLCs are high pressure homogenization or hot melt-emulsification. Figure 4 portrays the morphological layout depicting the drug distribution in lipid nanoparticles, SLNs and NLCs, respectively.
Solid lipid nanoparticles (SLNs) are the third generation nanostructured colloidal carriers ranging in size between 1 and 1000 nm, frequently used as an alternative over traditional polymeric nanoparticles. Their colloidal dimension provides high drug pay load, controlled drug release, drug targeting, drug protection and stability. Upon peroral delivery, SLNs are readily taken up by intestinal lymphatics owing to their lipidic nature and nanosized structure to enhance the oral bioavailability. The increasing attention in SLNs is due to their combined biodegradable and bio-acceptable nature coupled with efficient drug delivery characteristics and hassle-free method of preparation vis-a-vis polymeric nanoparticles.
Nanostructured lipidic carriers (NLCs), another third generation of nanoparticles, size ranging between 10 and 1000 nm, consist of mixture of solid and liquid lipids. Incorporation of liquid lipid can improve the loading capacity of drugs in the NLCs. Such NLCs tend to overcome the limitations of SLNs such as risk of gelation, uncontrolled release, decreased chemical stability and drug leakage during storage due to polymorphism of lipids. Commonly employed methods to produce NLCs are high pressure homogenization or hot melt-emulsification. Figure 4 portrays the morphological layout depicting the drug distribution in lipid nanoparticles, SLNs and NLCs, respectively.
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